Ondamsetron Hydrochloride and Sodium Chloride Injection
Name: Ondansetron Hydrochloride and Sodium Chloride Injection Main ingredients: ondansetron hydrochloride
Structural formula : C18H19N3O HCL·2H2O
Mol wt: 365.83
Description The product is clear colorless liquid.
Pharmacology and toxicity
pharmacologic action: a selective 5-HT3 receptor antagonist. While the mechanism of action has not been fully characterized, it may through Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Thus block the vomiting reflex that caused by chemotherapy and operation appear to be associated with release of serotonin from the enterochromaffin cells of the small intestine, the released serotonin may stimulate the vagal afferents through the 5-HT3 receptors. This product has higher selectivity, without side effect such as extracorticospinal tract reaction, over sedative.
Action and usage:
Prevention of nausea and vomiting associated with cytotoxicity drug chems and radiotherapy, also it is suitable for preventing and curing nausea and vomiting after operation.
1. Anti-tumor adjuvant drug
2. Potent and highly selective 5-HT3 receptor antagonists
3. It has a strong anti-vomiting function and has no side effects of other anti-emetics.